Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: features of pathomorphological diagnostics
DOI:
https://doi.org/10.14739/2310-1237.2012.1.15292Keywords:
MALT-lymphoma of the stomach, pathomorphological diagnosticsAbstract
On the base of our own observations and literature data it was determined that the distinctive pathologic features of MALT-lymphoma of the stomach is tight diffuse lymphocytic infiltrate in the lamina propria between the reactive lymph follicles and glands of the mucous membrane by centrocyte-like tumor cells of marginal zone, monocytoid B-lymphocytes, small lymphocytes, plasma cells and a single large centroblasts-like or immunoblasts-like cells, the presence of zones "lymphoepithelial lesions" of glands due to infiltration by tumor cell aggregates, and Dutcher bodies in plasma cells. The main immunophenotypic feature of the MALT-lymphoma is the presence of diffuse immun cell infiltration by CD20+, IgM+, IGD-B-cells outside the reactive follicles mantle zone. Immunophenotype of tumor MALT-lymphoma cells is identical to the immunophenotype of marginal zone B-cells, the reaction with antibodies against CD5, CD10 and CD23 is negative. It was described molecular and genetic disorders, histologic evidence of lymphoma varying degrees of malignancy, stages of stomach MALT-lymphoma to select the method of patient’s treatment.
References
Casini A. Collagen type I synthesized by pancreatic periacinar stellate cells (PSC) co-localizes with lipid peroxidation-derived aldehydes in chronic alcoholic pancreatitis / Casini A., Galli A., Pignalosa P., et al. // J Pathol. – 2000. – №192. – Р. 81–89.
Vogelmann R. Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-β1 transgenic mouse model / Vogelmann R., Ruf D., Wagner M., et al. // Am J Physiol Gastrointest Liver Physiol. – 2001. – №280. – Р. 164–172.
Jaster R. Molecular regulation of pancreatic stellate cell function / Jaster R. // Mol. Cancer. – 2004. – Vol. 3. – Р. 26–32.
Benyon R.C. Extracellular matrix degradation and the role of hepatic stellate cells / Benyon R.C., Arthur M.J.P. // Semin Liver Dis. – 2001. – №21. – Р. 373–384.
Leco K.J. Murine tissue inhibitor of metalloproteinases-4 (TIMP-4): cDNA isolation and expression in adult mouse tissues / Leco K.J., et al. // FEBS Letters. – 1997. – Vol. 401. – P. 213–217.
McCawlley L.J. Matrix metalloproteinases: they’re not just for matrix anymore! / McCawlley L.J., Matrisian L.M. // Curr Opin. Cell boil. – 2001. – Vol. 12. – P. 534–546.
Phillips P. A. Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover / Phillips P. A., McCarroll J.A., Park S., et al. // Gut. – 2003. – №52 (2). – Р. 275–282.
Michalski Ch. W. Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis / Michalski Ch.W.,Gorbachevski A., Erkan M.J. // Transl Med. – 2007. – Vol. 5. – Р. 63–70.
Apte M.V. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis / Apte M.V., et al. // Gut. – 1999. – Vol. 44. – Р. 534–541.
Shek F.W.-T. Expression of Transforming Growth Factor-β1 by Pancreatic Stellate Cells and Its Implications for Matrix Secretion and Turnover in Chronic Pancreatitis / Shek F.W.-T., Benyon R.Ch., Walker F.M // Am J Pathol. – 2002. – Vol. 160(5). – Р. 1787–1798.
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