Morphologic changes of blood – gas barrier in acute respiratory distress syndrome in the experiment
DOI:
https://doi.org/10.14739/2310-1237.2012.1.15856Keywords:
surfactant of the lungs, acute respiratory distress-syndrome, the treatment, the morphologyAbstract
Changes in the lungs of nonlinear white rats with a modeled acute respiratory distress syndrome without any therapy are characterized by progression of destructive necrotic processes with increasing of exudation and infl ammatory infi ltration during all 6 days of experiment. Infl ammatory reactions are replaced by fi brosis when simultaneous antibacterial and substitutive surfactant therapy is applied. Administration of only antibacterial therapy leads to prolongation of destructive infl ammatory process and deceleration of fi brosis appearance by 6 day of experiment.
References
Глумчер Ф.С. Острый респираторный дистресс-синдром: определение, патогенез, терапия / Ф.С. Глумчер // Мистецтво лікування. – 2004. – №9. – С. 30–35.
Межирова Н.М. Патофизиологические и диагностические аспекты синдрома системного воспалительного ответа / Н.М. Межирова, В.В. Данилова, С.С. Овчаренко // Медицина неотложных состояний. – 2011. – №1–2. – C. 32–33.
Плотников Г.П. Лечение вирусно-бактериальных пневмоний у беременных и родильниц в период сезонного гриппа 2009 г. (многоцентровое исследование)/ Г.П. Плотников, Д.Л. Шукевич, Ю.А. Чурляев [и др.] // Общая реаниматология. – 2010. – Т. 6, №5. – С. 5–10.
Stapleton R D. Causes and Timing of Death in Patients With ARDS/ R.D. Stapleton, B.M. Wang, L.D. Hudson [et al.]// Chest. –2005. – №128. – P. 525–532
Рекалова Е.М. Поражения легких в период пандемии свиного гриппа А(H1N1) 2009–2010 гг. / Е.М. Рекалова // Клиническая иммунология. Аллергология. Инфектология. – 2010. – №3. – С. 42–48.
Mary B.B. The Pathologist's Approach to Acute Lung Injury/ B.B. Mary // Archives of Pathology & Laboratory Medicine. – 2010. – Vol. 134, №5. – P. 719–727.
Sabater J. Effects of an omega-3 fatty acid-enriched lipid emulsion on eicosanoid synthesis in acute respiratory distress syndrome (ARDS): A prospective, randomized, double-blind, parallel group study/ J. Sabater, J. R. Masclans, J. Sacanell [at al.] // Nutrition & Metabolism (London). – 2011. – V. 8. – P. 8–22.
Orme J.Jr. Pulmonary function and health-related quality of life in survivors of acute respiratory distress syndrome/ J.Jr. Orme, J.S. Romney, R.O. Hopkins [et al.]//Am. J. Respir. Crit. Care. Med. – 2003. – №167. – P. 690–694.
Barrios RJ. Hypersensitivity pneumonitis: histopathology/ R.J. Barrios//Arch. Pathol. Lab. Med. – 2008. – №132 (2). – P. 199–203.
Shieh WJ. 2009 pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States/ W.J. Shieh, D.M. Blau, A.M. Denison [et al.] // Am. J. Pathol. – 2010. – №177 (1). – P. 13–14.
Stevens T. Lung Vascular Cell Heterogeneity. Endothelium, Smooth Muscle, and Fibroblasts / Stevens T., Phan S., Frid M.G. et al. // The Proceedings of the American Thoracic Society. – 2008. – V. 5. – P. 783–791.
Kox M. The selective α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates ventilator-induced inflammation and lung injury / M. Kox, J.C. Pompe, M. Vaneker [et al.] // Critical Care. – 2009. – №13. – P. 55.
Hegeman M.A. Systemic administration of E-selectin-directed dexamethasone liposomes attenuates pulmonary inflammation in a mouse model of ventilator-induced lung injury/ M.A. Hegeman, P.M. Cobelens, M.P. Hennus., [et al.] // Critical Care. – 2009. – №13. – P. 327.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
