Metabolism of connective tissue structures violation in the debut of rheumatoid arthritis
DOI:
https://doi.org/10.14739/2310-1237.2012.1.15858Keywords:
oxyproline, early rheumatoid arthritis, C-terminal telopeptides of type I collagenAbstract
The aim of the study was to assess the signifi cance of connective tissue metabolism violations as the marker of infl ammatory and destructive processes in patients with rheumathoid arthritis (RA). 168 patients with duration of rheumatoid arthritis from 6 to 24 months were examined. Serum blood content of glycosaminoglycans (GA) and oxyproline (OP) were determined for all the subjects. It is proved that progression of infl ammatory and destructive processes in joints in patients with RA is potentiated by increased level of oxyproline and glycosaminoglycans and varies depending on duration of the disease.
References
Gabriel S.E. The epidemiology of rheumatoid arthritis / S.E. Gabriel // Rheum Dis Clin North Аmer. – 2001. – №27. – Р. 269–281.
Association of baseline levels of urinary glucosyl-galactosyl-pyridinoline and type II collagen C-telopeptide with progression of joint destruction in patients with early rheumatoid arthritis / P. Garnero, E. Gineyts, S. Christgau et al. // Arthritis Rheum. – 2002. – №46. – Р. 21–30.
Иммунологические реакции к антигенам соединительной ткани у больных ревматоидным артритом, системной склеродермией и системной красной волчанкой / Ж.И. Авдеева, М.М. Захарова, П.П.Рассохина и др. // Тер. архив. – 1980. – Т. 52, №11. – С. 122–126.
Серов В.В. Соединительная ткань / Серов В.В., Шехтер А.Б. – М.: Медицина, 1981. – 312 с.
Effects of infliximab therapy on biological markers of synovium activity and cartilage breakdown in patients with rheumatoid arthritis / H. Marotte, E. Gineyts, P. Miossec, et al. // Ann Rheum Dis. – 2009. – №68. – Р. 1197–2000.
Increased degradation and altered tissue distribution of cartilage oligomeric matrix protein in human rheumatoid and osteoarthritic cartilage / P.E. Di Cesare, C.S. Carlson, E.S. Stolerman et al. // J. Orthop. Res. – 1996. – Vol. 14, №6. – P. 946–955.
Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. Implications for pathogenesis / A.R. Poole, M. Lonescu, A. Swan et al. // J.C1in.Invest. – 1994. – Vol. 94, №1. – P. 25–33.
Inflammation and cartilage metabolism in rheumatoid arthritis. Studies of blood markers hyaluronic acid, orosomucoid. and keratan sulfate / A.R. Poole, J. Witter, N. Robertset al. // Arthr.Rheum. – 1990. – Vol. 33. – P. 790–799.
Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting / P. Qvist, S. Christgau, BJ. Pedersen, et al. // Bone. – 2002. – №31. – Р. 57–61.
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