Pathogenesis, patomorphological features and histologic differential diagnostics of primary, recurrent and secondary aneurysmal bone cysts in children and teenagers
DOI:
https://doi.org/10.14739/2310-1237.2012.1.15860Keywords:
aneurysmal bone cyst, secondary aneurysmal bone cysts, recurrent aneurysmal bone cysts, histologic differential diagnosisAbstract
The purpose of this study was the following: on the basis of the analysis of own biopsy-histologic material to establish the features of pathomorphologic changes which are observed in the lesion foci of primary, recurrent and secondary aneurysmal bone cysts (ABC) in children and teenagers and which are the basis of their differential histologic diagnosis. АBC passes cyclic development that is the progressing stage which is characterized by high resorptive-proliferative activity and increase of volume focus, the stabilization stage when the focus volume increase stops, and the regression stage when fi brosing and ossifi cation of capsular-septal structures prevail,
including osteosclerosis, with remodelling of bone elements and some decrease of focus dimensions. Some part of total number of all АBC make up secondary hemorrhagic cysts which arise in the foci of a pathologic tissue in other tumours and tumorlike lesions of bones. An incomplete removal of pathologic tissue of ABC with properties of high resorptive activity with respect to the adjacent bone tissue should be considered the main reason of ABC-reccurence after surgical treatment.
References
Григоровский В.В. Аспекты клинической патологии, морфологической дифференциальной диагностики и патогенеза аневризмальных костных кист / В.В. Григоровский // Ортопед. травматол. – 1999. – №3. – С. 122–127.
Григоровський В.В. Номенклатура, гістологічні особливості та диференціальна діагностика гігантоклітинних проліферативних уражень кісток у дітей та підлітків / В.В. Григоровський // Онкология. – 2002. – Т. 4, №3. – С. 174–183.
Григоровский В.В. Патоморфологические изменения, отражающие биологические процессы в кальций-фосфатных имплантатах, при пластике остаточных полостей в костях человека / В.В. Григоровский, Р.В. Лучко, Л.А. Зотиков // Вестн. травматол. и ортопед. им. Н.Н. Приорова. – 2008. – №1. – С. 82–88.
Денисов-Никольский Ю.И. Морфологические особенности аневризмальных костных кист у детей / Ю.И. Денисов-Никольский, Е.Н. Борхунова, А.А. Докторов [та ін.] // Арх. патологии. – 2002. – №2. – С. 19–23.
Крись-Пугач А.П. Рецидиви аневризмальних кіст кісток у дітей та підлітків: можливі причини та нез’ясовані теоретичні питання / А.П. Крись-Пугач, Ю.М. Гук, В.В. Григоровський [та ін.] // Вісник ортопедії, травматол. та протезув. – 2011. – №1. – С. 5–10.
Семенова Л.А. Аневризмальная киста кости у детей / Л.А.Семенова, О.А. Малахов, К.В. Жердев // Арх. патологии. – 2010. – №4. – С. 55–58.
Снетков А.И. Особенности течения активной аневризмальной кисты в детском возрасте (описание случая) / А.И. Снетков, З.Г. Нацвлишвили, Г.Н. Берченко [та ін.] // Вестн. травматол. и ортопед. им. Н.Н.Приорова. – 2003. – №2. – С. 86–89.
Abuhassan F.O. Subperiosteal resection of aneurysmal bone cysts of the distal fibula / F.O. Abuhassan, A.O. Shannak // J. Bone and Joint Surg. – 2009. – V. 91-B, №9. – P. 1227–1231.
Althof P.A. Cytogenetic and molecular cytogenetic findings in 43 aneurysmal bone cyst: aberrations of 17p mapped to 17p13.2 by fluorescence in situ hybridization / P.A. Althof, K. Ohmori, M. Zhou [та ін.] // Modern Pathol. – 2004. – V. 17. – P. 518–525.
Arkader A. Benign Bone Tumors of the Upper Extremities in Children / A.Arkader // J. Pediatr. Orthop. – 2010. – V. 30, Suppl. – P. S21–S26.
Basarir K. Aneurysmal bone cyst reccurence in children: A review of 56 patients / K.Basarir, A.Piskin, B.Guglu [та ін.] // J. Pediatr. Orthop. – 2007. – V. 27. – P. 938–943.
Chan G. Primary aneurysmal bone cyst of the epiphysis / G. Chan, A. Arkader, J.P. Dormans [та ін.] // Clin. Orthop. Rel. Res. – 2010. – DOI 10.1007/s11999-010. – P. 1228–1235.
Chia-Chen Hsu. Osteosarcoma at the Site of a Previously Treated Aneurysmal Bone Cyst. A Case Report / Chia-Chen Hsu, Jun-Wen Wang, Cheng-Hua Huang [та ін.] // J. Bone and Joint Surg. – 2005. – V. 87-A, №2. – P. 395–398.
Cottalorda J. Modern concepts of primary aneurysmal bone cyst / J. Cottalorda, S. Bourelle // Arch. Orthop. Trauma Surg. – 2007. – V. 127, №1. – P. 105–114.
De Silva M.V.C. Fibromyxoid areas and immature osteoid are associated with recurrence of primary aneurysmal bone cysts / M.V.C. De Silva, N. Raby, R. Reid // Histopathology. – 2003. – V. 43, №2. – P. 180–188.
Jiong G. Malignant transformation of aneurysmal bone cyst / G. Jiong, G. You-Shui, W. Shu-Ging [та ін.] // Chin Orthop. – 2009. – V. 122, №1. – P. 110–112.
Leithner A. Aneurysmal Bone Cyst: a Hereditary disease? / A. Leithner, F. Machacek, O.A. Haas [та ін.] // J. Pediatr. Orthop. B. – 2004. – V. 13, №3. – P. 214–217.
Lin P.P. Aneurysmal Bone Cysts Recur at Juxtaphyseal Locations in Skeletally Immature Patients / P.P. Lin, Ch. Brown, A.K. Raymond [та ін.] // Clin. Orthop. Rel. Res. – 2008. – V. 466, №3. – P. 722–728.
Mankin H.J. Aneurysmal bone cyst: A Review of 150 Patients / H.J. Mankin, F.J. Hornicek, E. Ortiz-Cruz [та ін.] // J. Clin. Oncol. – 2005. – V. 23, №27. – P. 6756–6762.
Mendenhall W.M. Aneurysmal Bone Cyst / W.M. Mendenhall, R.A. Zlotecki, C.P. Gibbs [та ін.] // Am. J. Clin. Oncol. – 2006. – V. 29, №3. – P. 311–315.
Oliveira A.M. Aneurysmal Bone Cyst: A Neoplasm Driven by Upregulation of the USP6 Oncogene / A.M. Oliveira, M.M. Chon, A.R. Perez-Atayde [та ін.] // J. Clin. Oncol. – 2006. – V. 24, №1. – P. e1.
Pathology and Genetics of Tumours of Soft Tissue and Bone. WHO Classification of Tumours / Ed. C.D.M. Fletcher, K.K. Unni, F. Mertens. – Lyon: IARC Press, 2002. – 427 p.
Peeters S.P. Aneurysmal bone cyst: The role of cryosurgery as local adjuvant treatment / S.P.Peeters, J.C.M. VanderGeest, J.W.J. de Rooy [та ін.] // J. Surg. Oncol. – 2009. – V. 100, №8. – P. 719–724.
Rossi G. Selected arterial embolization of 36 aneurysmal bone cysts of the skeleton with N-2-butyl cyanoacrylate / G. Rossi, E. Rimondi, T. Bartalena [та ін.] // Skeletal Radiol. – 2010. – V. 39, №2. – P. 161–167.
Szendroi M. Aneurysmal bone cyst: Its pathogenesis based on angiographic, immunohistochemical and electron microscopic studies / M. Szendroi, G. Arato, A. Ezzati [та ін.] // Pathol. Oncol. Res. – 1998. – № 4. – P. 277–281.
Topouchian V. Aneurysmal bone cyst in children: complications of fibrosing agent injection / V. Topouchian, K. Mazda, B. Hamze [та ін.] // Radiology. – 2004. – V. 232. – P. 522–526.
Sherwani R.K. Giant cell tumor along secondary aneurysmal bone cyst of scapula: A rare presentation / R.K. Sherwani, S. Zaheer, A.B. Sabir [та ін.] // Int. J. Shoulder Surg. – 2008. – V. 2, №3. – P. 59–61.
Zehetgruber H. Prevalence of Aneurysmal and Solitary Bone Cysts in Young Patients / H. Zehetgruber, B. Bittner, D. Gruber [та ін.] // Clin. Orthop. Rel. Res. – 2005. – № 439. – P. 136–143.
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
