Role of transcription factor Cdx2 in the development of gastric intestinal metaplasia
DOI:
https://doi.org/10.14739/2310-1237.2012.2.16720Keywords:
intestinal differentiation transcription factor Cdx2, intestinal metaplasia, gastric mucosaAbstract
The role of intestinal differentiation transcription factor Cdx2 in the development of gastric intestinal metaplasia was established on the basis of its expression in material of gastric mucosa biopsies. Taking into account of CDX2 expression intensity the diagnostic algorithm of gastric intestinal metaplasia for further tactics of patients management was proposed.References
Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1 / W.M. Carol Chan, A. Wong Newton , Liu Yinget et al. // PNAS. – 2009. – Vol. 106, №6. – P. 1936–1941.
Mutoh H. Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice / H. Mutoh, S. Sakurai, K. Satoh et al. // Gut. – 2004. – Vol. 53. – P. 1416–1423.
Metaplasia – A Transdifferentiation Process that Facilitates Cancer Development: The Model of Gastric Intestinal Metaplasia / P. Mesquita, A. Raquel, N. Lunet et al. // Critical ReviewsTM in Oncogenesis. – 2006. – Vol. 12 (1–2). – P. 3–26.
Cassaro M. Indefinite for non-invasive neoplasia lesions in gastric intestinal metaplasia: the immunophenotype/ Cassaro M., Rugge M., Tieppo C. et al. // J Clin Pathol. – 2007. – Vol. 60. – P. 615–621.
Transcription of Sonic Hedgehog, a Potential Factor for Gastric Morphogenesis and Gastric Mucosa Maintenance, Is Up-regulated in Acidic Conditions / Dimmler A., Brabletz T., Hlubek et al. // Laboratory investigation. – 2003. – Vol. 83, №12. – P. 1829–1837.
CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer / Qiang L., Ming T., Kosei I.. et al. // Modern Pathology. – 2007. – Vol. 20. – P. 1286–1297.
The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development / Bonhomme C., Duluc I., Martin E. et al. // Gut. – 2003. – Vol. 52. – P. 1465–1471.
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