The prognostic value of p16ink4a marker in the diagnosis of cervical dysplasia

Authors

  • E. A. Dyadyk
  • Yu. I. Pokolodnaya

DOI:

https://doi.org/10.14739/2310-1237.2012.2.16743

Keywords:

cervix, dysplasia, immunohistochemical study

Abstract

The morphological study of 110 cervical biopsies from patients with suspected cervical intraepithelial neoplasia (dysplasia) was performed with the help of  immunohistochemical method using marker р16ink4a. This method confirmed the diagnosis of dysplasia, made after histological study, only in 56% of patients. Thus, for better assessment of the presence and degree of dysplasia of cervical epithelium it is advisable to include an identification of cyclin kinase inhibitor  р16ink4a in the diagnostic algorithm.

References

Richart R.M. Cervical intraepithelial neoplasia / R.M. Richart // Gynecol Oncol. − 1973. – Vol. 19. − Р. 301–328.

Бохман Я.В. Руководство по онкогинекологии / Я.В. Бохман. − М.: Медицина, 1989. − 174 с.

Heatley M.K. How should we grade CIN? / M.K. Heatley // Histopathology – 2002. – Vol. 40, №4. − Р. 377–390.

Киселев В.И. Молекулярные механизмы регуляции гиперпластических процессов: Монография / В.И. Киселев, А.А. Ляшенко. – М.: «Дмитрейд график групп», 2005. – 346 с.

Procedure for immunocytochemical detection of p16INK4A antigen in thin-layer, liquid-based specimens / [Bibbo M., Klump W.J., DeCecco J., Kovatish A.J.] // Acta Cytol. – 2002. – Vol. 46. – Р. 25–29.

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Published

2013-08-29

How to Cite

1.
Dyadyk EA, Pokolodnaya YI. The prognostic value of p16ink4a marker in the diagnosis of cervical dysplasia. Pathologia [Internet]. 2013Aug.29 [cited 2024Apr.24];(2). Available from: http://pat.zsmu.edu.ua/article/view/16743

Issue

No. 2 (2012)

Section

Original research

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