Features of expression of protein Claudin 11 at various forms of male infertility

Authors

  • S. V. Bazalytska
  • A.M. Romanenko
  • Yu. V. Persidsky

DOI:

https://doi.org/10.14739/2310-1237.2012.3.16986

Keywords:

male infertility, protein Claudin 11

Abstract

Immunohistochemical features of an expression of  protein Claudin 11 in testicular tissue of 28 patients with excretory-obstructive and secretory forms of male infertility  are studied. Significant decrease of  protein Claudin 11 IHC expression level at the secretory form of male infertility and at syndrome «only Sertoli cells» is revealed in comparison with excretory-obstructive form of male infertility. Results testify to considerable disturbances of blood-testis barrier, which have become the basis of the development of additional immune component and intensification of pathological changes in patients with the secretory form of male infertility.

References

Wu X. Transgene-mediated rescue of spermatogenesis in Cldn11-null / Wu X., Peppi M., Vengalil M.J., Maheras K.J., Southwood C.M., Bradley M., Gow A. // Biol Reprod. – 2012. – Vol. 86 (5), №139. – P. 1–11.

Mazaud-Guittot S. Phenotyping the claudin 11 deficiency in testis: from histology to immunohistochemistry / Mazaud-Guittot S., Gow A., Le Magueresse-Battistoni B. // Methods Mol. Biol. – 2011. – №763. – P. 223–236.

Mazaud-Guittot S. Claudin 11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testis / Mazaud-Guittot S., Meugnier E., Pesenti S., Wu X., Vidal H., Gow A., Le Magueresse-Battistoni B. // Biol. Reprod. – 2010. – Vol. 82 (1). – P. 202–213.

Florin A. Androgens and postmeiotic germ cells regulate claudin-11 expression in rat Sertoli cells / Florin A., Maire M., Bozec A., Hellani A., Chater S., Bars R., Chuzel F., Benahmed M. // Endocrinology. – 2005. – Vol. 146 (3). – P. 1532–1540.

Nah W.H. Claudin-11 expression increased in spermatogenic defect in human testes / Nah W.H., Lee J.E., Park H.J., Park N.C., Gye M.C. // Fertil. Steril. – 2011. – Vol. 95 (1). – P. 385–388.

Fink C. Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men / Fink C., Weigel R., Fink L., Wilhelm J., Kliesch S., Zeiler M., Bergmann M., Brehm R. // Histochem. Cell. Biol. – 2009. – Vol. 131 (6). – P. 755–764.

Юнда И.Ф. Бесплодие в супружестве / Юнда И.Ф., Иванюта Л.И., Имшинецкая Л.П. – К.: Здоровье, 1990. – 464 с.

Malmstrum P.U. Expression of ABH blood group isoantigen as a prognostic factor in transitional cell bladder carcinoma / Malmstrum P.U., Busch C., Norben B.J., Andersson B. // Scand. J. Urol. Nephrol. – 1998. – Vol. 22. – P. 265–270.

Chihara M. Molecular dynamics of the blood-testis barrier components during murine spermatogenesis / Chihara M., Otsuka S., Ichii O., Hashimoto Y., Kon Y. // Mol. Reprod. Dev. – 2010. – Vol. 77 (7). – P. 630–639.

Xu J. Zona occludens-2 is critical for blood-testis barrier integrity and male fertility / Xu J., Anuar F., Ali S.M., Ng M.Y., Phua D.C., Hunziker W. // Mol. Biol. Cell. – 2009. – Vol. 20 (20). – P. 4268–4277.

Allegrucci C. Circulating human antisperm antibodies recognize prostasomes / Allegrucci C., Ronquist G., Ove Nilsson B. et al. // Am. J. Reprod. Immunol. – 2001. – Vol. 46 (3). – P. 211–219.

Bohring C. Isolation and identification of sperm membrane antigens recognized by antisperm antibodies, and their possible role in immunological infertility disease / Bohring C., Krause E., Habermann B., Krause W. // Mol. Hum. Reprod. – 2001. – Vol. 7 (2). – P. 113–118.

Bohring C. Immune infertility: towards a better understanding of sperm (auto)-immunity. The value of proteomic analysis / Bohring C., Krause W. // Hum. Reprod. – 2003. – Vol. 18 (5). – P. 915–924.

Chiu W.W. Use of antisperm antibodies in differential display Western blotting to identify sperm proteins important in fertility / Chiu W.W., Chamley L.W. // Hum. Reprod. – 2002. – Vol. 17(4). – P. 984–989.

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How to Cite

1.
Bazalytska SV, Romanenko A, Persidsky YV. Features of expression of protein Claudin 11 at various forms of male infertility. Pathologia [Internet]. 2013Aug.29 [cited 2024Apr.25];(3). Available from: http://pat.zsmu.edu.ua/article/view/16986

Issue

No. 3 (2012)

Section

Original research

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