Features of expression of protein Claudin 11 at various forms of male infertility

Authors

  • S. V. Bazalytska
  • A.M. Romanenko
  • Yu. V. Persidsky

DOI:

https://doi.org/10.14739/2310-1237.2012.3.16986

Keywords:

male infertility, protein Claudin 11

Abstract

Immunohistochemical features of an expression of  protein Claudin 11 in testicular tissue of 28 patients with excretory-obstructive and secretory forms of male infertility  are studied. Significant decrease of  protein Claudin 11 IHC expression level at the secretory form of male infertility and at syndrome «only Sertoli cells» is revealed in comparison with excretory-obstructive form of male infertility. Results testify to considerable disturbances of blood-testis barrier, which have become the basis of the development of additional immune component and intensification of pathological changes in patients with the secretory form of male infertility.

References

Wu X. Transgene-mediated rescue of spermatogenesis in Cldn11-null / Wu X., Peppi M., Vengalil M.J., Maheras K.J., Southwood C.M., Bradley M., Gow A. // Biol Reprod. – 2012. – Vol. 86 (5), №139. – P. 1–11.

Mazaud-Guittot S. Phenotyping the claudin 11 deficiency in testis: from histology to immunohistochemistry / Mazaud-Guittot S., Gow A., Le Magueresse-Battistoni B. // Methods Mol. Biol. – 2011. – №763. – P. 223–236.

Mazaud-Guittot S. Claudin 11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testis / Mazaud-Guittot S., Meugnier E., Pesenti S., Wu X., Vidal H., Gow A., Le Magueresse-Battistoni B. // Biol. Reprod. – 2010. – Vol. 82 (1). – P. 202–213.

Florin A. Androgens and postmeiotic germ cells regulate claudin-11 expression in rat Sertoli cells / Florin A., Maire M., Bozec A., Hellani A., Chater S., Bars R., Chuzel F., Benahmed M. // Endocrinology. – 2005. – Vol. 146 (3). – P. 1532–1540.

Nah W.H. Claudin-11 expression increased in spermatogenic defect in human testes / Nah W.H., Lee J.E., Park H.J., Park N.C., Gye M.C. // Fertil. Steril. – 2011. – Vol. 95 (1). – P. 385–388.

Fink C. Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men / Fink C., Weigel R., Fink L., Wilhelm J., Kliesch S., Zeiler M., Bergmann M., Brehm R. // Histochem. Cell. Biol. – 2009. – Vol. 131 (6). – P. 755–764.

Юнда И.Ф. Бесплодие в супружестве / Юнда И.Ф., Иванюта Л.И., Имшинецкая Л.П. – К.: Здоровье, 1990. – 464 с.

Malmstrum P.U. Expression of ABH blood group isoantigen as a prognostic factor in transitional cell bladder carcinoma / Malmstrum P.U., Busch C., Norben B.J., Andersson B. // Scand. J. Urol. Nephrol. – 1998. – Vol. 22. – P. 265–270.

Chihara M. Molecular dynamics of the blood-testis barrier components during murine spermatogenesis / Chihara M., Otsuka S., Ichii O., Hashimoto Y., Kon Y. // Mol. Reprod. Dev. – 2010. – Vol. 77 (7). – P. 630–639.

Xu J. Zona occludens-2 is critical for blood-testis barrier integrity and male fertility / Xu J., Anuar F., Ali S.M., Ng M.Y., Phua D.C., Hunziker W. // Mol. Biol. Cell. – 2009. – Vol. 20 (20). – P. 4268–4277.

Allegrucci C. Circulating human antisperm antibodies recognize prostasomes / Allegrucci C., Ronquist G., Ove Nilsson B. et al. // Am. J. Reprod. Immunol. – 2001. – Vol. 46 (3). – P. 211–219.

Bohring C. Isolation and identification of sperm membrane antigens recognized by antisperm antibodies, and their possible role in immunological infertility disease / Bohring C., Krause E., Habermann B., Krause W. // Mol. Hum. Reprod. – 2001. – Vol. 7 (2). – P. 113–118.

Bohring C. Immune infertility: towards a better understanding of sperm (auto)-immunity. The value of proteomic analysis / Bohring C., Krause W. // Hum. Reprod. – 2003. – Vol. 18 (5). – P. 915–924.

Chiu W.W. Use of antisperm antibodies in differential display Western blotting to identify sperm proteins important in fertility / Chiu W.W., Chamley L.W. // Hum. Reprod. – 2002. – Vol. 17(4). – P. 984–989.

Downloads

How to Cite

1.
Bazalytska SV, Romanenko A, Persidsky YV. Features of expression of protein Claudin 11 at various forms of male infertility. Pathologia [Internet]. 2013Aug.29 [cited 2024Nov.13];(3). Available from: http://pat.zsmu.edu.ua/article/view/16986

Issue

No. 3 (2012)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Лицензия Creative Commons
    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).