The relationship between the levels of melatonin and testosterone in male rats of different ages with ulcer of the stomach
DOI:
https://doi.org/10.14739/2310-1237.2015.2.48622Keywords:
Melatonin, Testosterone, Ulcer, Stomach, Male, RatsAbstract
Seasonality and dependence of age and sex is an important question in the development of ulcer of the stomach. Melatonin has an important place among the hormones that are involved in the formation of ulcer of the gastric mucosa.
Aim. In order to establish the relationship between the levels of melatonin and testosterone in ulcerative lesions of the stomach in male rats of different ages their level in the blood serum was studied by enzyme immunoassay ELISA.
Methods and results. It was found that against the background of gastric ulceration a significant increase in melatonin levels and decrease in serum testosterone occur, most expressed in rats aged 9 months.
Conclusion. The obtained results indicate the presence of the relationship between melatonin and testosterone levels in both normal and pathological conditions.
References
Kvetnoy, I. M., Ingel, I. E., Kvetnaia, T. V., Malinovskaya, N. K., Rapoport, S. I., Raikhlin, N. T., et al. (2002). Gastrointestinal melatonin: cellular identification and biological role. Neuroendocrinology Letters, 23, 121–132.
Oparin, A. A., Shapovalova, O. E., Dvoiashkina, Yu. I., & Lavrova, N. V. (2010). Melatonin i zabolevaniya zheludochno-kishechnogo trakta [Melatonin and diseases of gastrointestinal tract]. Mezhdunarodnyj medicinskij zhurnal, 4, 68–72. [in Ukrainian].
Fares, A. (2013). Global patterns of seasonal variation in gastrointestinal diseases. J. Postgrad. Med., 59(3), 203–207. doi: 10.4103/0022-3859.118039.
Oh, S., & Oh, S. (2014). Epidemiologacal and genome-wide association study of gastritis or gastric ulcer in Korean populations. Genomics & Informatics, 12(3), 127–133. doi: 10.5808/GI.2014.12.3.127.
Thorsen, K., Soreide, J. A., Kvalov, J. T., Glomsaker, T., & Soreide, K. (2013). Epidemiology of perforated peptic ulcer: age- and gender-adjusted analysis of incidence and mortality. World. J. Gastroenterol., 19(3), 347–354. doi: 10.3748/wjg.v19.i3.347.
Stefanov, O. V. (2001) Doklinichni doslidzhennia likarskykh zasobiv [Preclinical studies of drugs]. Kyiv: Avicena. [in Ukrainian].
Kochetov, A. G., Lyang, O. V., Masenko, B. P., Zhirov, I. V., Nakonechnikov, S. N., & Tereshchenko, S. N. (2012). Metody statisticheskoj obrabotki medicinskikh dannykh [Statistical Treatment of Medical Data]. Moscow: RKNPK. [in Russian].
Bernasconi, P. A., Cardoso, N. P., Reynoso, R., Scacchi, P., & Cardinali, D. P. (2013). Melatonin and diet-induced metabolic syndrome in rats: impact on the hypophysial-testicular axis. Horm. Mol. Biol. Clin. Investig., 16(2), 101–112. doi: 10.1515/hmbci-2013-0005.
Maltseva, S. V., & Ishkina L. A. (2005). Kliniko-funkcional'noe znachenie melatonina pri khronicheskom gastroduodenite u podrostkov [Clinical and functional role of chromatophorotropic hormone in cases of adolescent gastroduodenitis]. Pediatriya, 5, 13–16. [in Russian].
Bondarenko, L. A. (2015) Nekotorye gormonal'nye mekhanizmy uskorennogo stareniya pri gipopinealizme [Some hormonal mechanisms of accelerated aging at gipopinealizme]. Dosiahnennia ta perspektyvy eksperymentalnoi ta klinichnoi endokrynolohii: Abstracts of Papers of the Scientific and Praktscal Conference, (pp. 14–20). Kharkiv. [in Ukrainian].
Frol'kis, V. V. (2008). Starenie: vospominanie o buduschem [Aging: Remembering the Future]. Medix Anti-Aging., 2, 8–12. [in Ukrainian].
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