Effect of expression of immunohistochemical marker Ki-67 on the life expectancy of patients with gastric cancer 0-III stages

Authors

  • O. M. Levyk
  • A. I. Shevchenko
  • V. A. Tumanskiy
  • A. V. Evseyev

DOI:

https://doi.org/10.14739/2310-1237.2015.2.50815

Keywords:

Сancer of Stomach, Ki-67 Antigen, Survival Rate

Abstract

In Ukraine 60,9% of patients with gastric cancer die within 1 year after ascertainment of diagnosis.

Aim: In order to investigate the effect of Ki-67 overexpression on life expectancy, study was conducted among 129 patients with gastric cancer of 0 - III stages, who received treatment in Zaporizhzhia Regional Clinical Oncology Center from June 2006 till October 2013.

Methods and results. All patients included in the study underwent radical surgical treatment. 62 patients with gastric cancer (48%) received adjuvant chemotherapy. Immunohistochemical study was performed using monoclonal antibodies Mo a-Hu Ki-67 Antigen, Clone MIB-1. It has been found that the Ki-67 overexpression is observed in 65,9% of the tumor tissue of gastric cancer patients and indicates aggressive process.

Conclusion. Using adjuvant chemotherapy among patients with gastric cancer  II stage significantly improves the life expectancy (p <0.05) in cases when patients have the presence of high Ki-67 proliferative activity.

References

Antoneeva, I. I., & Petrov, S. B. (2008). Markery apoptoza i proliferacii v dinamike progressirovaniya raka yaichnika [Markers of apoptosis and proliferation in the dynamics of the progression of ovarian cancer]. Oncology, 10(2), 234–237. [in Ukrainian].

Babichenko, I. I., & Kovyazin, V. A. (2008). Novye metody immunogistokhimicheskoj diagnostiki opukholevogo rosta [New methods of immunohistochemical diagnosis of tumor growth]. Moskow. [in Russian].

Delektorskaya, V. V. (2007). Molekulyarno-biologicheskie markery metastazirovaniya i prognoza pri rake tolstoj kishki (Dis… dokt. med. nauk). [Molecular biological markers of metastasis and prognosis in colorectal cancer. Dr. med. sci. diss.]. Moskow. [in Russian].

Pozharisskij, K. M., Ten, V. P., Maksimova, N. A., Samsonova, E. A., & Umancheeva, A. F. (2005). Immunogistokhimicheskij profil' e`ndometrioidnoj adenokarcinomy tela matki: ER, PR, HER-2, Ki-67 i ikh prognosticheskoe znachenie [Immunohistochemical profile endometrioid uterine adenocarcinoma: ER, PR, HER-2, Ki-67 and their prognostic value]. Arhiv patologii, 68(2), 13–17. [in Russian].

Kopnin, V. R. (2006) Sovremennye predstavleniya o mekhanizmakh zlokachestvennogo rosta [Modern understanding of the mechanisms of malignant growth]. Proceedings of the 10th Congress of the Russian Cancer,(pp. 99–102). Moscow. [in Russian].

Petrov, S. V., & Rajkhlin, N. T. (2004). Rukovodstvo po immunogistokhimicheskoj diagnostike opukholej cheloveka [Guide immunohistochemical diagnosis of human tumors]. Kazan' : Titul. [in Russian].

Pozharisskij, K. M., & Leenman, E. N. (2000). Znachenie immunogistokhimicheskikh metodik dlya opredeleniya kharaktera lecheniya i prognoza opukholevykh zabolevanij [The value of immunohistochemical techniques to determine the nature of the treatment and prognosis of neoplastic diseases]. Arkhiv patologii, 5, 3–11. [in Russian].

Fedorenko, Z. P., Gajserenko, A. V., Gulak, L. O., Gorokh, E. L., Ryzhov, A. U., Sumkina, O. V., & Kutsenko, L. B. (2010). Rak v Ukraine, 2009–2010 [Cancer in Ukraine, 2009–2010]. Byulleten' nacional'nogo kancer-reestra Ukrainy, 12, 37. [in Ukrainian].

Sabirov, A. Kh. (2010). Gistologicheskie, immunogistokhimicheskie i molekulyarno-geneticheskie markery raka molochnoj zhelezy, ikh prognosticheskaya znachimost' (Dis… dokt. med. nauk). [Histological, immunohistochemical and molecular genetic markers of breast cancer and their prognostic significance. Dr. med. sci. diss.] Tyumen`. [in Russian].

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How to Cite

1.
Levyk OM, Shevchenko AI, Tumanskiy VA, Evseyev AV. Effect of expression of immunohistochemical marker Ki-67 on the life expectancy of patients with gastric cancer 0-III stages. Pathologia [Internet]. 2015Oct.8 [cited 2024Nov.8];(2). Available from: http://pat.zsmu.edu.ua/article/view/50815

Issue

No. 2 (2015)

Section

Original research

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