Computer-morphometric analysis of nerve tissue edematous changes in progressive and stable cerebral infarction
DOI:
https://doi.org/10.14739/2310-1237.2015.2.50994Keywords:
Cerebral Infarction, Brain Edema, Computer MorphometryAbstract
Aim. To clarify the morphogenesis of perifocal critical zones of cerebral infarction we investigated 60 cases of patient's death from hemispheric cerebral infarction and conducted computer-morphometric study of the nervous tissue edema parameters.
Methods and results. It was defined that critical zones of infarctions both with progressive and stable clinical course as well as areas of the contralateral hemisphere tissue are characterized by significant prevalence of vasogenic edema component above the cytotoxic one which can indicate a predominant role of generalized, mostly vasogenic, nervous tissue edema in the mechanisms of tanatogenesis in this pathology. Critical zones in progressive flow variant differ by stable and high rate of both components of edema, unlike critical zones of stabilized variant of cerebral infarction.
Conclusion. The computer-morphometric data correspond pathohistologic features of critical zones, reflect peculiarities of its morphogenesis at different variants of clinical course of ischemic stroke. Consequently they can be used for differential retrospective pathomorphologic diagnostics of progressive and stable variants of cerebral infarction.
References
Michinaga, Sh., & Koyama, Yu. (2015) Pathogenesis of brain edema and investigation into anti-edema drugs. Int. J. Mol. Sci., 16, 9949–9975. doi:10.3390/ijms16059949.
Simard, M., Simard, M., Kent, Th., Chen, M., Tarasov, K. V., & Gerzanich, V. (2007). Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neuro, 6(3), 258–268. doi: 10.1016/S1474-4422(07)70055-8.
Thrane, A. S., Rangroo Thrane, V., & Nedergaard, M. (2014). Drowning stars: Reassessing the role of astrocytes in brain edema. Trends Neurosci., 37(11), 620–628. doi: 10.1016/j.tins.2014.08.010.
Mikhaenkova, N. V., Hudoerkov, R. M., & Gulevskaya, T. S. (2009) Morphologicheskie pokazateli perifocal`nykh zon infarkta v verkhnej visochnoj izviline kory bol`shogo mozga cheloveka [Morphological indicators of perifocal infarct zone in the superior temporal gyrus of the cerebral cortex of man]. Aktual'nye problemy biologii, nanotehnologij i mediciny Proceedings of the 3rd International Conference, (p. 143–144). Rostov-na-Donu. [in Russian].
Shavrin, V. A., & Shulyatnikova, T. V. (2011). Ul'trastrukturnye osobennosti sinapsov v kriticheskikh zonakh infarkta golovnogo mozga v e`ksperimente [The ultrastructural features of the synapses in the critical zones of cerebral infarction in the experiment]. Patologіia, 8(3), 90–93. [in Ukrainian].
Shulyatnikova, T. V., & Shavrin, V. A. (2012). Morfometricheskie pokazateli ostrogo nabukhaniya i uplotneniya nejronov v kriticheskoj zone ishemicheskogo infarkta mozga [The morphometric parameters of acute swelling and sealing of neurons in the critical zone of ischemic brain infarction]. Patologіia, 3(26), 93–95. [in Ukrainian].
Roldan-Valadez, E., & Lopez-Mejia, M. (2014). Current concepts on magnetic resonance imaging (MRI) perfusion-diffusion assessment in acute ischaemic stroke: a review & an update for the clinicians. Indian J Med Res, 140, 717–728.
Moritani, T., Ekholm, S., Westesson, Per-Lennart (2009). Diffusion-Weighted MR Imaging of the Brain. Springer Science & Business Media.
Dyadyk, E. A., & Polkovnikov, Yu. F. (2012). Rol' generalizovannogo oteka mozga v tanatogeneze pri ishemicheskom infarkte mozga (komp'yuterno-morfometricheskoe issledovanie) [The role of generalized cerebral edema in tanatogenesis in ischemic cerebral infarction (computer-morphometric study)]. Patologіia, 3(26), 91–92. [in Ukrainian].
Battey, T. K., Karki, M., Singhal, A. B., Wu, O., Sadaghiani, S., Campbell, B. C., et al. (2014). Brain edema predicts outcome after nonlacunar ischemic stroke. Stroke, 45(12), 3643–3648. doi: 10.1161/STROKEAHA.114.006884.
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
