Papillary thyroid carcinoma with biomineralization: clinical and morphological features

Authors

  • R. A. Moskalenko Sumy State University,
  • A. M. Romaniuk Sumy State University,
  • A. V. Rieznik
  • A. V. Kurochkin Sumy Regional Clinical Oncological Dispensary,
  • A. M. Piddubniy Sumy State University,
  • V. A. Lukash Sumy Regional Clinical Oncological Dispensary,

DOI:

https://doi.org/10.14739/2310-1237.2016.1.71182

Keywords:

Thyroid Cancer, Durapatite, Dystrophic Calcification

Abstract

Papillary thyroid cancer (PTCa) is the most common form of malignant tumors of this organ, covering approximately 70% in the structure of morbidity. Pathological biomineralization is often the first diagnostic sign of ultrasound of the thyroid, so the study of its morphological features is the purpose of our paper. A total of 30 PTCa samples with the signs of biomineralization and 30 PTCa samples without biomineralization were studied. The study used histological, histochemical techniques and scanning electron microscopy with X-ray diffraction. All PTCa patients who had the signs of pathological biomineralization were combined in the first group (30 people) – 27 women and 3 men (9:1). The average age of patients of the first group was 56.93±2.18 years old. The patients were diagnosed with different histological PTCa types: 22 cases of classic variant of PTCa, 3 cases of diffuse sclerotic variant, 2 cases of follicular, 2 cases of tall cell variant, and 1 case of solid variant of PTCa. Patients who had no signs of PTCa mineralization, made up the second group. 30 people – 24 women and 6 men (4:1) – were selected in to the second group. It was found out that in the first group the largest size of tumor site averaged 1.84±0.13 cm, and in the second group the rate was 1.44±0.09 cm (p<0.07). Comparing the number of patients with metastases in both groups (7 – I group, 8 – Group II) and describing the size of tumor nodules, subject to presence of metastases in patients (2.09±0.2 cm and 1.31±0.17 cm), there was significant difference found between indicators of clinical cases of studied groups (p<0.02).

The main mineral that is involved in the development of dystrophic calcification in case of PTCa is hydroxyapatite. The presence of hydroxyapatite is characteristic for all the types of PTCa biomineralization.

References

Ferlay J, Soerjomataram I, Dikshit R., Eser, S., Mathers, C., Rebelo, M., et al. (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer., 136(5), E359–E386. doi: 10.1002/ijc.29210.

Fedorenko, Z. P., Hulak, L. O., Horokh, Ye. L. (2006–2013) Rak v Ukraini, 2007–2013 [Cancer in Ukraine (from 2007 to 2013)]. Biuleten Natsionalnoho kantser­reiestru Ukrainy, 7–13. Retrieved from http://users.i.kiev.ua/~ucr/ [in Ukrainian].

Rieznik, A. V., Smiianov, V. A., Tarasenko, S. V., et al. (2015) Analiz zakhvoriuvanosti na zloiakisni pukhlyny shchytopodibnoi zalozy u Cumskii oblasti [Analysis of the incidence of malignant thyroid tumors in Sumy region]. J. Clin. Exp.Med. Res., 3(4), 609–617. [in Ukrainian].

LiVolsi, L. A. (2011) Papillary thyroid carcinoma: an update. Modern Pathology, 24, S1–S9. doi: 10.1038/modpathol.2010.129.

Sherman, S. I. (2003) Thyroid carcinoma. Lancet., 361(9356), 501–11.

Lin, J.-D., Hsueh C., & Chao, T.-C. (2009) Early Recurrence of Papillary and Follicular Thyroid Carcinoma Predicts a Worse Outcome. Thyroid, 19(10), 1053–1059. doi:10.1089/thy.2009.0133.

Kwak, J. Y., Kim, E-K., Son, E. J, Kim, M. J, Oh, K. K, Kim, J. Y., & Kim, K. I. (2007) Papillary thyroid carcinoma manifested solely as microcalcifications on sonography. Am J Roentgenol, 189, 227–31. doi: 10.2214/AJR.06.0750.

DiCiccio, T. J., & Efron, B. (1996) Bootstrap confidence intervals. Statistical Science., 11(3), 189–228.

Moskalenko, R. A., Rieznik, A. V., Hapchenko, A. V., Prokofieva, H. H., & Maltseva, A. S. (2015) Morfolohichne doslidzhennia shchytopodibnoi zalozy pry zakhvoriuvanniakh, yaki suprovodzhuiutsia biomineralizatsiieiu [Morphological examination of thyroid diseases accompanied by biomineralization]. Visnyk biolohii i medytsyny, 2, 3(120), 324–331. [in Ukrainian].

Rieznik, A. V., Gapchenko, A. V., Gapchenko, V. V., Starkiv, M. P., & Moskalenko, R. A. (2015) Ultrasonic echo of thyroid gland biomineralization. J. Clin. Exp. Med. Res., 3(2),188–198. [in Ukrainian].

Das, D. K. (2009) Psammoma body: a product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor? Diagn Cytopathol., 37(7), 534–41. doi: 10.1002/dc.21081.

Moskalenko, R., Romanyuk, А., Danilchenko, S., Stanislavov, O., Piddubniy, A., Zakorko, I. М., & Tkach, G. (2013) Morphogenetic aspects of biomineralization on the background of benign prostatic hyperplasia. Georgian medical news, 214(1), 54–61.

Danilchenko, S. N., Kuznetsov, V. N., Stanislavov, A. S., Kalinkevich, A. N., Starikov, V. V., Moskalenko, R. A., et al. (2013) The mineral component of human cardiovascular deposits: morphological, structural and crystal-chemical characterization. Crystal research and technology, 48(3), 153–62. doi: 10.1002/crat.201200443.

Moskalenko, R. A., Romanyuk, A. N., Danilchenko, S. N., Kozinets, N. I., Smeyanov, E. V., Kalinichenko, T. G., & Kuznetzov, V. N. (2014) Rare case of pathological biomineralization of eye tissue. Čes. a slov. Oftal., 70(4), 160–163.

How to Cite

1.
Moskalenko RA, Romaniuk AM, Rieznik AV, Kurochkin AV, Piddubniy AM, Lukash VA. Papillary thyroid carcinoma with biomineralization: clinical and morphological features. Pathologia [Internet]. 2016Jun.23 [cited 2024Apr.16];(1). Available from: http://pat.zsmu.edu.ua/article/view/71182

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Section

Original research